The Journal of Pathology. 245(3):283–296, JULY 2018
Issn Print: 0022-3417
Publication Date: July 2018
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
Daniel Temko;Inge Van Gool;Emily Rayner;Mark Glaire;Seiko Makino;Matthew Brown;Laura Chegwidden;Claire Palles;Jeroen Depreeuw;Andrew Beggs;Chaido Stathopoulou;John Mason;Ann‐Marie Baker;Marc Williams;Vincenzo Cerundolo;Margarida Rei;Jenny Taylor;Anna Schuh;Ahmed Ahmed;Frédéric Amant;Diether Lambrechts;Vincent Smit;Tjalling Bosse;Trevor Graham;David Church;Ian Tomlinson;
1Evolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK 2Centre for Maths and Physics in the Life Sciences and Experimental Biology (CoMPLEX) University College London London UK 3Department of Computer Science University College London London UK 4Department of Pathology Leiden University Medical Centre Leiden The Netherlands 5Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK 6KU Leuven (University of Leuven), University Hospitals Leuven, Department of Obstetrics and Gynaecology Division of Gynaecological Oncology Leuven Belgium 7KU Leuven, Department of Human Genetics Laboratory for Translational Genetics Leuven Belgium 8VIB Centre for Cancer Biology Laboratory for Translational Genetics Leuven Belgium 9Institute of Cancer and Genomic Sciences University of Birmingham Birmingham UK 10Department of Cell and Developmental Biology University College London London UK 11MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine University of Oxford Oxford UK 12Department of Oncology University of Oxford Oxford UK 13Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine University of Oxford Oxford UK 14Nuffield Department of Obstetrics & Gynaecology University of Oxford Oxford UK 15Centre for Gynaecological Oncology Amsterdam Netherlands Cancer Institute Amsterdam The Netherlands
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