STRUCTURE-BIOLOGICAL ACTIVITY RELATIONSHIP IN PROSTAGLANDIN ANALOGS

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Abstract

A complex of mathematical models for the recognition of antiulcer and uterotonic activity of prostaglandin analogs is developed based on SARD computer system, which provides for the activity recognition on a level of 86-98%. The most significant structural signs related to manifestations of the given biological properties are revealed. The established relationship between structure and biological activity of prostaglandin analogs will be used in the following research for constructing new compounds with preset properties.

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