SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF QUATERNARY DERIVATIVES AND MINERAL SALTS OF DIETHYLAMINOACETIC ACID ORTHO-TOLUIDIDE

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Abstract

A series of quaternary dervatives of diethylaminoacetic acid ortho-toluidide have been synthesized by reactions with various halogen-containing derivatives of alkanes, alkenes, and arylalkanes in acetone. The acute toxicity and antiarrhythmic activity of the synthesized compounds have been studied. Several compounds with antiarrhythmic activity exceeding that of a structural analog (lidocaine) are found and recommended for further investigation and practical implementation.

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