PHASE EQUILIBRIA IN DISPERSED SOLID SYSTEMS OF IBUPROFEN WITH PIRACETAM AND UREA AS HYDROPHILIC COMPONENTS

    loading  Checking for direct PDF access through Ovid

Abstract

The solid dispersion systems ibuprofen-piracetam and ibuprofen-urea have been studied by differential scanning calorimetry. It is established that these systems belong to the eutectic type. The points of nonvariant equilibrium of the ibuprofen-piracetam and ibuprofen-urea systems correspond to a 65:35 and 74:26 (mol%) ratio of components, respectively. The solubility of ibuprofen from the solid binary mixtures increases with increasing fraction of very soluble components. For the ibuprofen-piracetam and ibuprofen-urea eutectic systems, the solubility of ibuprofen increases by a factor of approximately 2 and 1.53, respectively, as compared to the pure substance alone.

Related Topics

    loading  Loading Related Articles