SYNTHESIS OF 2,4,6-TRIISOPROPYLBENZENESULFONIC ACID N-AZOLIDES AND THEIR REGULATORY EFFECT ON CELL PROLIFERATION, ENERGY EXPENDITURE, AND APOPTOSIS PROCESSES

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Abstract

A series of new N-azolides of 2,4,6-triisopropylbenzenesulfonic acid have been synthesized. Their biological activity with respect to the processes of cell proliferation, energy expenditure, and programmed cell death (apoptosis) has been studied. Convincing evidence is obtained for pronounced immunomodulating and cytoprotecting properties of two compounds (N-imidazolide and N-triazolide of 2,4,6-triiospropylbenzenesulfonic acid), which produce a positive influence directed at pathological states, in particular, cell proliferation, cell energy expenditure, and apoptosis.

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