SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 1, 3-DI(2-SUBSTITUTED 10H-PHENOTHIAZIN-10-YL)PROPAN-1-ONE

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Abstract

Aseries of 1,3-di(2-substituted 10H-phenothiazin-10-yl)propan-1-one (IVa – p) was synthesized by using the phenothiazine framework through a three-carbon atom chain by condensation of the different chlorides of 3-(10H-phenothiazin-10-y1)propionic acid (IIIa – d) with 2- substituted phenothiazines (Ia – d), and the structures of these compounds were confirmed by IR, 1H NMR, mass, and elemental analysis. The newly synthesized compounds were evaluated for antimicrobial activity.

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