Synthesis and biological activity ofn-acyl-4-phenyl-1,2-epoxy-2,3,3a,4,5,9b-hexahydro-1h-cyclopenta[c]quinolines

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Abstract

Oxidation of substituted N-acyl-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolines led to the corresponding 1,2-epoxides and 1,2-diols. The synthesized 1,2-epoxides were characterized with respect to acute toxicity, cytotoxicity, analgesic activity, and influence on locomotion and exploration in an open-field test.

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