The optimum composition and technology of Dermalic ointment consisting of the dense extract of licorice root and essential oils of chamomile and tea tree intended for the treatment of atopic dermatitis have been theoretically and experimentally validated. The results of biological tests were used to determine the optimum concentrations of active ingredients in the ointment. A water/oil emulsion base has been developed based on technological, physicochemical, and biopharmaceutical investigations. Methods for qualitative and quantitative determination of active ingredients in the preparation have been developed according to the State Pharmacopoeiaof Ukraine. The stability of the ointment during storage has been studied.