Previous research studies have found that audience response systems or “clickers” provide significant classroom, learning, and assessment benefits in higher education. However, there are few to no research studies that have pitted popular clicker systems against each other using data collected from a sample of millennial students in public health–related professions. As a result, the purpose of this study was to compare two popular audience response systems in the college classroom with undergraduate students, specifically those studying public health. The study was implemented using a mixed methods quasi-experimental crossover design with three observation points over one academic year. Both qualitative and quantitative data were collected. Findings suggest that undergraduate students prefer using a dedicated “clicker” system to respond to questions from an audience response system than a system that requires them to use their personal cell phones.