Opsoclonus-Myoclonus and Anti-Hu Positive Limbic Encephalitis in a Patient With Neuroblastoma†

    loading  Checking for direct PDF access through Ovid

Abstract

Opsoclonus-myoclonus syndrome (OMS) is seen in 2–3% of children with neuroblastoma and is believed to be caused by an autoimmune process elicited by the tumor. Although long-term neurologic sequelae are common in children with OMS, limbic encephalitis has not previously been reported. We report a child who developed limbic encephalitis associated with anti-Hu antibodies, 6 years after her initial diagnosis of neuroblastoma and OMS. This case demonstrates that patients with neuroblastoma and OMS are at risk for developing new paraneoplastic symptoms years after their original diagnosis and emphasizes the need for careful long-term follow-up. Pediatr Blood Cancer 2012; 58: 472–474. © 2011 Wiley Periodicals, Inc.

Related Topics

    loading  Loading Related Articles