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Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown.Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg × 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning.All five patients remain in molecular remission a median of 20 months post-transplant.Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation. Pediatr Blood Cancer 2008;51:521–524. © 2008 Wiley-Liss, Inc.