Immune-mediated mechanism for thrombocytopenia afterLoxoscelesspider bite

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Loxoscelism, characterized by high fever, vomiting, malaise, a dermonecrotic lesion, and thrombocytopenia, was diagnosed in a 3-year-old female. Clinical laboratory and dermatological signs are described. Blood test showed a transient hypercoagulable state and the presence of IgG antibodies against platelets, suggesting an immune-mediated mechanism for platelet destruction, in addition to the direct toxic effect of the spider venom. The finding of platelet antibodies after a Loxosceles spider bite has not been previously reported. Pediatr Blood Cancer 2014; 61:1466–1468. © 2014 Wiley Periodicals, Inc.

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