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Tetanus is a life-threatening, preventable disease. It is most commonly acquired from a wound site; however, it can be obtained via injuries of other tissues. Both primary and secondary measures of prevention contribute to the eradication of tetanus. Therefore, appropriate tetanus prophylaxis should be administered in a timely fashion when patients present with wounds or infected tissue. Because tetanus prevention can be so effective, it is imperative to review, document, and address any tetanus deficiencies.