AMANTADINE PENETRATION INTO CEREBROSPINAL FLUID OF A CHILD WITH INFLUENZA A ENCEPHALITIS


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Abstract

The use of amantadine has been advocated as treatment for influenza A encephalitis despite limited information regarding cerebrospinal fluid concentrations and the pathogenesis of encephalitis associated with influenza virus infections. We report a 2-year-old child with influenza A encephalitis treated with amantadine who achieved a potentially therapeutic concentration in cerebrospinal fluid. Despite this the child developed significant neurologic impairment.

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