GENE POLYMORPHISM OF IFNG +874 T/A AND TLR4 +896 A/G AND RECURRENT INFECTIONS AND WHEEZING IN TODDLERS WITH HISTORY OF BRONCHIOLITIS


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Abstract

Cytokine and TLR4 polymorphisms and their association with the infection history of 129 children hospitalized for bronchiolitis during the first 6 months of life were analyzed. The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4+896 A/G allele G were more likely to need tympanostomy than noncarriers.

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