Predictive value of gelsolin for the outcomes of preterm neonates: A pilot study

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Background:Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.Methods:A total of 32 preterm neonates born at 23–32 weeks of gestation were enrolled in the study.Results:Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).Conclusions:Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.

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