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Asthma is the most common chronic illness for children and affects children worldwide. Non-compliance with clinical practice guidelines compromises pediatric asthma management. The two-fold purpose of this study was to implement clinical practice assessments outlined by the Global Initiative for Asthma and to examine the effect of the asthma control test and peak expiratory flow interventions on pulmonary referral and hospitalization rates of pediatric patients with asthma. The goal was to emphasize the significance of implementing clinical practice guidelines in caring for pediatric patients with asthma. A pre-intervention and post-intervention retrospective chart review was completed to assess the effectiveness of clinical practice guidelines in decreasing hospitalizations and pulmonary specialist referrals in a rural pediatric clinical setting. Outcomes revealed an increase in pulmonology referrals and hospitalizations. Use of clinical practice guidelines help to identify poorly controlled pediatric patients with asthma and the need for acute care intervention, revision of pharmacological therapy, or pulmonology referrals. Clinical practice guidelines are influential in managing pediatric asthma. Evidence-based practice must be used to promote optimal short- and long-term outcomes in all healthcare settings.