Catch-up Growth in Cortisone–Treated Rats: Effects of Calcium and Vitamin D

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Abstract

Summary

The aim of the study was to develop an animal model of steroid stunting and catch-up growth and to investigate the possibility that calcium supplements, with or without vitamin D supplements, might mitigate the effects of corticosteroids on linear growth.

Speculation

The growth retardation induced by cortisone may be partly related to direct effects on the skeleton. Vitamin D may improve catch-up growth by antagonizing the effects of corticosteroids on the growth plate.

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