High Lipoprotein(a) in Children from Kindreds with Parental Premature Myocardial Infarction

    loading  Checking for direct PDF access through Ovid



In 98 children from 98 kindreds, 49 with and 49 without parental premature myocardial infarction (age ≤45 y), our specific aim was to determine whether, and to what degree, lipoprotein(a) [Lp(a)] and other atherogenic lipids and lipoproteins might be overexpressed in children from premature infarction kindreds. Median Lp(a) (270 mg/L) in case boys was nearly twice that in control boys (140 mg/L) (p ≤ 0.001). In a logistic regression model including age, Quctelet index (relative ponderosity), Lp(a), apo Al, apo B, triglyceride, and pubcrtal status, the 24 case boys had higher Lp(a) (p = 0.03), higher triglyceride (p = 0.036), and marginally lower apo Al (p = 0.06) than the 26 control boys. Median Lp(a) in case girls (200 mg/L) was much higher than in control girls (150 mg/L) (p ≤ 0.01). In a logistic regression model including age, Quetelet index, Lp(a), apo Al, apo B, triglyceride, and menarchal status, Lp(a) was higher (p = 0.02), apo B was marginally higher (p = 0.07), and apo Al was lower (p = 0.008) in 25 case girls than in 23 control girls. Reflecting familial clustering of major lipid-lipoprotein risk factors for coronary heart disease, children from kindreds with premature parental myocardial infarction were distinguished from children from control kindreds by high Lp(a) and also had higher apo B and triglyceride and lower apo Al levels.

Related Topics

    loading  Loading Related Articles