Vigintiphobia, Unbound Bilirubin, and Auditory Brainstem Responses.

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Abstract

Methods

ABRs and serum UBCs in 37 hyperbilirubinemic term newborns (total bilirubin concentrations (TBCs) >=20 mg/dL and direct bilirubin concentrations <2 mg/dL) were measured before treatment with either phototherapy or exchange transfusions. Eight of these newborns had blood incompatibilities. These hyperbilirubinemic newborns were divided into three groups according to the findings of ABR: group A, normal ABR (n = 18); group B, prolonged latency of wave I only (n = 8); and group C, prolonged interpeak latency of wave I-III/I-V and/or poor amplitude (n = 11).

Results

The peak TBC was significantly different between groups A and C (22.8 +-/2.2 mg/dL and 25.4 +-/2.5 mg/dL, respectively; P < .05), though there were no differences between groups A and B and between groups B and C. The peak UBCs in groups B (1.27 +-/0.7 micrograms/dL) and C (1.34 +-/0.37 micrograms/dL) were significantly higher than in group A (0.78 +-/0.26 micrograms/dL) (P < .05 and P < .01, respectively), though there was no significant difference in the peak UBC between groups B and C. Abnormal ABR findings were more clearly associated with the level of UBC at 1.0 micrograms/dL than that of TBC at 23 mg/dL by multiple logistic regression analysis (odds ratio = 16.6, P = .0026, vs 4.2, P = .1272).

Conclusions

These results suggest that measuring UBC may help in evaluating the possible risk of bilirubin encephalopathy in full-term newborns when there is vigintiphobia (fear of 20). Pediatrics 1994;93:50-53; hyperbilirubinemia, vigintiphobia, unbound bilirubin, auditory brainstem responses, newborn.

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