Acculturation to mainstream and heritage culture has been shown to influence attitudes and behaviors related to romantic relationships. Few studies have examined its influence on views regarding interracial relationships and whether the psychological processes underlying these relations vary across gender. Among Chinese Canadian participants (N = 248), mainstream acculturation, but not Chinese acculturation, was associated with more personal openness to and less cultural values conflict about interracial relationships. Among men, stronger egalitarian gender role ideology mediated the relations between mainstream acculturation and the above interracial relationship variables. For women, fewer concerns about cultural preservation mediated the relation between mainstream acculturation and less cultural values conflict. The importance of understanding cultural influences on interracial relationships through a gendered lens is discussed.