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This study was undertaken to establish an animal model of extracorporeal membrane oxygenation in rabbits.Ten New Zealand white rabbits weighing 2573±330 g were used in this study. Extracorporeal membrane oxygenation was established in these animals through cannulation of the right carotid artery and jugular vein for arterial perfusion and venous return. The components of the perfusion circuit were specially designed. Arterial blood pressure was measured with a blood pressure meter through cannulation of the right femoral artery. The heart rate and blood gas parameters were also monitored by electrocardiography and a blood gas analyzer (Radiometer ABL800, Bronshøj, Denmark), respectively.The rabbit model of extracorporeal membrane oxygenation was established successfully. The hemodynamic and blood gas parameters were changed within an acceptable range during the extracorporeal membrane oxygenation process. The specially designed miniature membrane oxygenator was sufficient to meet the extracorporeal membrane oxygenation needs in this animal model.The rabbit model of extracorporeal membrane oxygenation established through right carotid artery and jugular vein cannulation is feasible, easily operated and economical. It is an ideal model for further research of the pathophysiology and organ protection offered through the application of extracorporeal membrane oxygenation.