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Hand washing is one of the oldest methods of reducing infections. Recent evidence based research has re-confirmed the efficacy of proper hand hygiene and recommendations for hand hygiene by the CDC and WHO are outlined. The PACU is a unique environment; patients are in a “cross-road of infection;” many patients are exposed to infections coming from various wards brought to the PACU through the OR. The PACU nurse is not only responsible for observing and monitoring the patient's vital signs but is also responsible for making sure patients are not exposed to an additional risk, e.g. a hand-transmitted infection.