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This quasi-experimental study compares manual compression and use of hemostatic patch in achieving hemostasis after femoral sheath removal. Patients who agreed to participate were randomly assigned to either control group or study. A majority of the patients (75.3%, n = 67) had a diagnostic procedure, and 24.7%, (n = 22) had an interventional procedure. The mean compression time for the control group (mean = 13.87, standard deviation [SD] = 5.6) was 2.5 minutes longer compared with the mean compression time for the study group (mean = 11.42, SD = 3.17). A statistically significant difference was found between groups, t = 2.782, (86, P < .001). No patients developed bleeding or hematoma during their stay or within 48 to 72 hours after discharge. No significant difference was found in pain scores between groups. There was no relationship between body mass index, abdominal girth, or pelvic girth to pressure time.