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Clinical Pharmacy includes all services performed by pharmacists practicing in hospitals, community pharmacies, nursing homes, home-based care services, clinics and any other setting where medicines are prescribed and used. Clinical Pharmacy activities may influence the correct use of medicines at three different levels: before, during and after the prescription is written. At the same time, pharmaceutical care philosophy is coming to Brazil. This paper comments on the development of the Clinical Pharmacy concept in Brazil, mainly in its practice and experience in the University Hospital of São Paulo.