Ethanol extracts of the aerial parts of sixHypericumspecies,H. barbatum, H. androsaemum, H. richerii, H. hirsutum, H. perforatumandH. perforatumcultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan-induced rat paw edema test. It was found thatall examined extracts produced antiinflammatory activity, particularly those fromH. hirsutum,and both wild and cultivatedH. perforatum.A dose-dependent antiinflammatory effect was especially pronounced in extracts showing some lower antiinflammatory activity. There was no correlation between the amount of hypericin in the extracts and their antiinflammatory activity. Copyright © 2006 John Wiley & Sons, Ltd.