The antioxidant and apoptotic activities of digallic acid, isolated from the fruits ofPistascia lentiscus, were investigated. The study demonstrated that digallic acid possessed pro-apoptotic effects, as shown by provoking DNA fragmentation of K562 cells. It also revealed a significant antioxidant potential and effective scavenging activity against 2,2-diphenyl-1-picrylhdrazyl (DPPH·) and O2·− radicals, and reduced cupric ions. We conclude that this integrated approach to apoptotic and antioxidant assessment may be useful to maximize the beneficial effects associated with usingP. lentiscusderivatives as medicinal and dietary compounds. Copyright © 2011 John Wiley & Sons, Ltd.