Kavalactone Metabolism in the Isolated Perfused Rat Liver

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Metabolic pathways for kavalactone metabolism in humans and rats have been identified, but more detailed description of the enzyme kinetics involved is lacking. The disposition profiles of three of the six major kavalactones (kavain, methysticin and desmethoxyyangonin) and their respective metabolites (p-hydroxykavain,m,p-dihydroxykavain andp-hydroxy-5,6-dehydrokavain) were examined in the perfusate and bile of the isolated perfused rat liver. The metabolism of the kavalactones is first-order in nature with similar decay half-lives.p-Hydroxykavain andm,p-dihydroxykavain were the only metabolites detected in the perfusate. Kavalactone biliary excretion was negligible. Copyright © 2012 John Wiley & Sons, Ltd.

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