Successful Immunotherapy in Life-threatening Parvovirus B19 Infection in a Child

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Abstract

We report a case of an immunocompetent child who developed parvovirus B19 infection complicated by autoinflammatory disease with myocarditis, tamponade and macrophage activation syndrome. He recovered with immunotherapy including prednisone, immunoglobulins, cyclosporin and anakinra (anti–interleukin-1). The report shows that parvovirus can provoke severe systemic inflammation with acute heart injury and that anti–interleukin-1 might be considered in such parvovirus-related inflammation.

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