Clinical Evaluation of Vancomycin Dosage in Pediatric Oncology Patients

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Abstract

Vancomycin trough serum concentrations were below therapeutic range (8–15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

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