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Chikungunya virus caused an epidemic on Curaçao in 2014–2015. Infants are highly at risk for clinical syndromes as sepsis-like illness and central nervous system disease. Clinical recognition is important if laboratory test, polymerase chain reaction and enzyme-linked immunosorbent assay are not available. The World Health Organization created criteria for identification of probable Chikungunya virus. None of the studied infants met these criteria. We believe the criteria suggested by World Health Organization should be modified for infants.