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In a prospective cohort of children hospitalized for bronchiolitis, we examined the rate of and characteristics associated with bronchiolitis relapse. Bronchiolitis relapse was documented in 22 (6%) of 391 children, and median time to relapse was 2 (interquartile range, 1–7) days. Relapse occurred more often in males. Prenatal smoking and smoke exposure in the home were also associated with relapse.