pineal research | 2014(03) articles

• Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures
• Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation
• Changes in melatonin levels in transgenic ‘Micro-Tom’ tomato overexpressing ovine AANAT and ovine HIOMT genes
• Melatonin prevents pancreatic β -cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress
• Melatonin prevents experimental preterm labor and increases offspring survival
• Age-related changes in mitochondrial function of mouse colonic smooth muscle: beneficial effects of melatonin
• Melatonin treatment combined with treadmill exercise accelerates muscular adaptation through early inhibition of CHOP-mediated autophagy in the gastrocnemius of rats with intra-articular collagenase-induced knee laxity
• Melatonin synthesis in rice seedlings in vivo is enhanced at high temperatures and under dark conditions due to increased serotonin N -acetyltransferase and N -acetylserotonin methyltransferase activities
• Pulmonary function changes in rats with taurocholate-induced pancreatitis are attenuated by pretreatment with melatonin
• Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression
• Melatonin improves neuroplasticity by upregulating the growth-associated protein-43 (GAP-43) and NMDAR postsynaptic density-95 (PSD-95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long-term recovery period