Limited research has taken an intersectional approach in which masculinity, ethnicity, and social class are collectively considered in understanding Latino men’s well-being. This study aims to address this gap by examining the role of perceived social class, familismo, acculturation, enculturation, Mexican American attitudinal marginalization, and masculinity ideology on well-being for 134 Mexican American college men ranging in age from 17 to 42 years (M = 20.64, SD = 3.92). Hierarchical multiple regression results indicated that men felt more satisfied with their lives when they perceived themselves to be of higher social class, adhered to familismo and to Mexican culture, expressed lower levels of marginalized attitudes toward Mexican American cultural norms, and had less traditional male role attitudes. The model collectively accounted for 26% of the variance in well-being, with perceived social class being the strongest predictor. The implications for practice and research are discussed in relation to understanding Latino men’s well-being within the context of intersectionality and masculinity.