This study applied a psychosociocultural framework to examine 95 Latino male undergraduates’ experiences of microaggressions, coping strategies, and etic and emic well-being. The most prominent microaggression reported was being constantly aware that they were one of few Latinos on campus. To cope with their microaggressions, Latino men most frequently found out more about a situation and took a positive, planned action. Problem-focused coping predicted both etic and emic well-being. Barriers to staying in school also predicted etic well-being, while anger and ethnic identity also predicted emic well-being. Practical implications are discussed in light of the study’s findings.