Intraoperative I-PTH provides immediate confirmation of the surgical outcome. Even more importantly, in nonlocalized cases, comparison of baseline PTH concentrations in right versus left internal jugular vein samples directs the surgical exploration and lessens surgical time spent on the case. In re-exploration cases, PTH levels from the jugular veins can show if there is parathyroid function on the side of the neck with a previously operated gland. From the point of view of a medical technologist, one of the most rewarding advantages of doing IO PTH is the close interaction with the surgical team. It raises job satisfaction and empowers technologists to be actively involved during an operation and delivers results that can immediately and visibly enhance patient outcome.