Point-of-care testing (POCT) is one of the fastest growing sectors in diagnostics, becoming a well-established laboratory tool in healthcare systems across the world. Recent research has focused on increasing cost-effectiveness and improving overall performance of existing POCT. Lower costs as well as rapid and accurate results have allowed for POCT to be used in resource-limited regions and positively impact patient care globally. Literature on POCT published between January 1, 2016 and December 31, 2016 was reviewed. Select articles are summarized and grouped into the following categories: hematology and coagulation, cardiac disease, infectious disease and human immunodeficiency virus, gastrointestinal disease, emergency medicine, glucose and diabetes, technological advancements, and other.