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Although metabolic and cardiovascular effects of resistance exercise in type 1 diabetes (T1DM) remain poorly explored, research employing type 2 diabetes suggests glycaemic and cardiovascular benefits. However, this intense exercise carries some risks.Here we describe the cardiovascular and metabolic responses of a newly diagnosed, previously sedentary T1DM individual experiencing syncope during an unaccustomed acute bout of resistance exercise.The cause of this exercise-induced incident was attributed to inappropriate cardiovascular control and lack of habituation to accompanying acid-base disturbances. Careful consideration of exercise intensity and progression in previously sedentary T1DM performing resistance exercise sessions is warranted. Copyright © 2013 John Wiley & Sons.