The authors describe a 23-year-old woman with Gorham’s syndrome who underwent an uneventful bilateral reduction mammoplasty which has not been reported in the medical literature today. The patient had undergone multiple surgical and medical interventions before presentation in the senior author’s clinic including a vascularized free fibular graft which ultimately disappeared due to disease progression. Preoperatively, the patient complained of debilitating neck and back pain secondary to her macromastia, which was noted to be asymmetric. A standard inferior pedicle breast reduction was performed with the removal of 600 g from the right breast and 400 g from the left. The patient healed well postoperatively without complication and was satisfied with her result.