The impact of fetal gender on first trimester nuchal translucency and maternal serum freeβ-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies

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To investigate if fetal sex has an impact on 1st trimester combined screening for aenuploidy.


We studied the first trimester PAPP-A, free β-human chorionic gonadatropin (β-hCG) and nuchal translucency levels in 56 024 normal, singleton pregnancies with known fetal sex at birth. We also examined the distributions in 722 pregnancies with trisomy 21 of known fetal sex.


We have found a 14.74% increase in first trimester maternal serum (MS) median free β-hCG MoM, 6.25% increase of PAPP-A and a 9.41% decrease in delta NT, when the fetus was female. Analysis of data has shown that women carrying a female fetus were 1.084 times more likely to be in the ‘at risk’ group than those carrying a male fetus. In examining data from 722 pregnancies in which the fetus was affected by trisomy 21, we observed a similar 20.8% increase in free β-hCG MoM, 5.7% increase in PAPP-A and a 12% decrease in delta NT when the fetus was female. Amongst the trisomy 21 cases, 88.8% of male trisomy 21 cases were detected compared with 91.2% in female cases, this difference was not statistically significant. Correcting for fetal sex redressed the balance in screen-positive rate between the sexes and had a minimal impact on detection rate.


Correcting for fetal sex may be a worthwhile consideration. A cost-benefit analysis would be required to determine if it is feasible to introduce fetal gender assignment into the routine first trimester scan for the purpose of marker correction and whether this would have any significant impact.

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