Maternal serum levels of neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9) and their complex MMP-9/NGAL in pregnancies with preeclampsia and those with a small for gestational age neonate: a longitudinal study


    loading  Checking for direct PDF access through Ovid

Abstract

BackgroundThe aim of this study was to determine maternal serum concentrations of neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9), and MMP-9/NGAL complex longitudinally in pregnancy, in normal pregnancies, in pregnancies that developed preeclampsia and in pregnancies that delivered a small for gestational age infant (SGA).MethodsNeutrophil gelatinase-associated lipocalin, MMP-9, and MMP-9/NGAL were determined in the first, second, and third trimesters in 33 normal pregnancies, 12 pregnancies complicated by preeclampsia, and 14 pregnancies that delivered a SGA neonate.ResultsMedian NGAL concentration (ng/mL) in normal pregnancies increased significantly from 12.8 in the first trimester to 25.9 in the second trimester (p = 0,002) and 48.0 (p < 0.0001) in the third trimester. In preeclamptic pregnancies, NGAL was significantly higher, compared with normal pregnancies, in the first (30.9; p = 0.006) and second (44.6; p = 0.015) trimesters. MMP-9 and MMP-9/NGAL complex concentrations in preeclamptic pregnancies did not differ significantly from normal pregnancies in either trimester. Pregnancies with an SGA infant did not have different marker concentrations in either trimester, compared with normal pregnancies.ConclusionMaternal serum NGAL, MMP-9, and MMP-9/NGAL complex concentrations tend to increase during pregnancy in normal and preeclamptic pregnancies. NGAL was significantly elevated in the first and second trimesters, in pregnancies that later developed preeclampsia. © 2014 John Wiley & Sons, Ltd.What's already known about this topic?Maternal serum NGAL and MMP-9 levels increase during pregnancy in both normal and preeclamptic pregnancies. Preeclamptic pregnancies had elevated NGAL levels in the first and second trimesters, compared with normal pregnanciesWhat does this study add?Our study confirms that NGAL levels are elevated in preeclamptic pregnancies at least in the first and second trimesters, compared with normal pregnancies. The MMP-9/NGAL complex is measured for the first time throughout pregnancy in normal and preeclamptic pregnancies. Pregnancies that delivered SGA neonates are considered as a separate group for the evaluation of NGAL, MMP-9, and their complex.

    loading  Loading Related Articles