Analysis of PGT-M and PGT-SR outcomes at a Canadian fertility clinic


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Abstract

ObjectiveOutcomes from in vitro fertilization (IVF)/intrauterine insemination (ICSI) cycles for patients who underwent preimplantation genetic testing for monogenic/single gene (PGT-M) and structural chromosome rearrangements (PGT-SR) patients were reviewed. Patients pursuing PGT-M and PGT-SR often do not have pre-existing fertility issues and therefore may have uncertain expectations of successful outcomes. Before pursuing PGT-M and PGT-SR, patients require evidence-based counseling regarding the probability of having a healthy child.MethodRetrospective review from a single private IVF clinic of 73 PGT patients, from whom a total of 437 blastocysts were biopsied and screened. Embryo results and pregnancy outcomes were analyzed.ResultsOf the 45 PGT-M patients, 64.4% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 89.7%, with an ongoing pregnancy or delivery rate of 48.9%. For the 28 PGT-SR patients, 60.7% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 87.5%, with an ongoing pregnancy or delivery rate of 42.9%.ConclusionThis information can supplement the existing data in the literature to counsel new patients in terms of realistic expectations of success following PGT-M and PGT-SR.What is already known about this topic?To our knowledge, three studies have been published on PGT-M and PGT-SR embryo outcomes. One was in London, one was in France, and one in China.What does this study add?To our knowledge, this is the only review of PGT-M and PGT-SR embryo and pregnancy outcomes published in North America.This paper explains how the information can help improve genetic counseling patients considering PGT-M and PGT-SR.

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