Evaluation of Retinoids as Therapeutic Agents in Dermatology

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Evaluation of 13- cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11- cis,13- cis-12-hydroxymethylretinoic acid, δ-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.

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