Continuous improvement of clinical care and outcomes is always the goal of medical science. Within posttraumatic stress disorder (PTSD) treatment, innovations may focus on improving access and overcoming barriers to effective interventions as well as improving efficacy. Innovations may include entirely novel interventions, augmentation of new strategies to known effective interventions, or modification of known effective interventions to increase retention, speed of response, or overall impact. Exciting work on innovations is underway with PTSD experts and others coming from all areas of neuroscience and technology to bridge the gap. We present some of the most promising innovations in PTSD treatment through application of innovations with clinical case examples and examine areas for future continued development through improving access and efficacy of PTSD treatments.