Aluminum (26Al) Metabolism in Rats (44159)


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Abstract

Abstract.Because of the lack of a suitable isotope and a sensitive technique of analysis, aluminum has been studied indirectly using analogs such as 67Ga (t1/2 = 78 hr). Recently, with the development of accelerator mass spectrometry (AMS), it has become possible to use the artificially produced radionuclide of aluminum, aluminum 26 (26Al), (t1/2 = 7.16 × 105 years). AMS is used for measuring long-lived and stable isotopes with the sensitivity of an attomole (10−17 mol). To study aluminum metabolism, 26AlCl3 was administered to rats intraperitoneally (ip) by injection and orally by gavage (n = 3/group). Blood was collected periodically. On Day 8 following perfusion, blood, liver, kidney, femur, brain, and spleen were collected and analyzed for 26Al. Of all the tissues studied, 26Al accumulation was greatest in the bone. 26Al accumulated in tissues as: bone > spleen > kidney ≃ liver > brain, but absorption was low (0.97% of dose). AMS offers great potential in Al research as it is the only technique available for tracer aluminum study.

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