Occupational health psychology (OHP) is a rapidly expanding interdisciplinary field. This article attempts to describe a framework of organizing principles and core competencies associated with OHP practice. These concepts are illustrated in a case study of an organizational health center (OHC) implemented within a large industrial complex. The OHC was designed to optimize both organizational health and individual well-being by applying behavioral science principles to a workplace setting producing both quantitative and qualitative benefits for the organization. The OHC program components, enveloped in a preventive stress management context, provide examples of the variety of opportunities in OHP with hopes of stimulating your own ideas for practice. Continuing to build and refine both the guiding theory and applications of OHP practice will yield benefits for organizational clients, practitioners, and the profession.