Because of the increasing complexity of work in people's lives and the rapid ways in which work is changing, it is likely that all applied psychologists will need greater content knowledge about work to assist clients with issues related to work choice, entry, and adjustment. This article identifies 5 knowledge domains about work that include important information for applied psychologists. These domains are as follows: (a) economics and politics, (b) work structures, (c) globalization, (d) social factors, and (e) technology. These 5 domains are outlined, as are anticipated future trends in work. The implications of these issues for applied psychologists are discussed.