Noninsulin-Dependent Diabetes Mellitus as a Mitochondrial Genomic Disease (44321)

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Abstract

Abstract.

The genetics of diabetes mellitus is very complex. Although the phenotypes are relatively simple vis-à-vis an abnormal glucose-insulin relationship, a number of genotypes share this phenotype. This review focuses on mutations in the mitochondrial genome that phenotype as diabetes mellitus. Studies in the human and the rat are described.

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