Polygenic Scores for Education, Health, and Personality as Predictors of Subjective Age Among Older Individuals of European Ancestry: Evidence From the Health and Retirement Study

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Abstract

The present study aimed to identify whether polygenic scores (PGSs) for education, health and psychological factors are related to subjective age in a large sample of older adults. Participants were 7,763 individuals of European ancestry (57% women, Mean age = 69.15, SD = 10.18) from the Health and Retirement Study who were genotyped and provided subjective age data. Higher PGSs for educational achievement and well-being were related to a younger subjective age, whereas higher PGSs for neuroticism, body mass index, waist circumference, and depressive symptoms were associated with an older subjective age. This study provides new evidence on the potential genetic underpinnings of subjective age.

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