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Recent research has drawn attention to factors that influence adjustment to an amputation. This paper is aimed at integrating these findings with prior studies and providing guidelines for psychologists who work with this population. We highlight five key issues that clinicians should attend to: 1) amputation is a diverse disability; 2) discrimination by others; 3) self-stigma; 4) feeling vulnerable to victimization; and 5) the role of values, meaning and perspective in positive adjustment. Recommendations for future research are provided.